Brain & Behavior

At present, a first line of experiments concerns the role of the prefrontal cortex, the hippocampus and their interactions for spatial short-term memory ("working memory"). Disorders of this memory system are an essential and disabling clinical feature of major neurological and psychiatric disorders like Alzheimer's disease and schizophrenia. We investigate the role of spatial working memory for human behavior by using psychophysical and neuropsychological methods in patients with focal lesions of the brain and healthy humans.