Enzephalitis & Paraneoplasia
The presence of antibodies against one’s own nervous system can lead to multifaceted symptoms, extending from disturbance of consciousness, character changes and memory disturbances, to possible epileptic seizures, movement disturbances, psychoses and paralysis. The prognosis depends decisively on the type of disease: disease with antibodies against the surface of nerve cells can often respond well to immunotherapy. In other patients, an autoimmune reaction is triggered by a tumor present in the body.
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Antibody-Mediated and Paraneoplastic Neurologic Diseases
The treatment and aftercare of patients with paraneoplastic neurologic diseases and autoimmune brain inflammation is carried out in the university outpatient clinic Encephalitis & Paraneopasis.
- Anti-NMDA receptor encephalitis
- encephalitis with GABA(B) receptor, AMPA receptor, mGluR5, ABA(A) receptor, GAD GFAP, Glycin, DPPX, VGKC complex antibodies (incl. LGl1, Caspr2)
- limbic encephalitis
- paraneoplastic Brain inflammantion (e.g. with Anti-Hu, -Yo, -Ri,-, Amphiphysin, Ma1, Ma2, CV2 Antibodies)
- antibody-mediated dementia
- brain inflammation (e.g. encephalitis through Herpes viren
- Morvan syndrome
- obsoclonus myoclonus syndrome
A brief explanation of most of these diseases can be found in:
Prüß, Harald: „Neuroimmunologie: Neues zur limbischen Enzephalitis“ in Aktuelle Neurologie 2013; 40: 127-136.
The most famous patient with an anti-NMDA receptor:
Encephalitis, Berlin’s Polar Bear Knut: Prüss H, Leubner J, Wenke NK et. al.: „Anti-NMDA Receptor Encephalitis in the Polar Bear (Ursus maritimus) Knut“ in Sci Rep. 2015; 5:12805.